Revidia Therapeutics

Pioneering drug therapies to reverse heart damage.

What if injured heart muscle could be regenerated…
just by taking a drug? 

Revidia Therapeutics, Inc. is developing first-in-class small molecule drugs that activate intrinsic regenerative and repair mechanisms in damaged heart muscle.

Our lead drug candidate, MSI-1436, is the only small molecule in development that activates regeneration in the adult mammalian heart.

Duchenne muscular dystrophy (DMD) is an incurable rare muscle wasting disease. Heart failure is the leading cause of death for most DMD patients.... but there is hope.

Dilated cardiomyopathy and heart failure

DMD patients develop dilated cardiomyopathy that ultimately leads to heart failure. There are no approved therapies for DMD cardiomyopathy. Most DMD therapies under development focus on reducing skeletal muscle symptoms. Revidia’s first-to-clinic application of MSI-1436 will be as a treatment for DMD cardiomyopathy with multiple follow-on cardiac indications.

Unmet clinical need

DMD genetic and cell therapies have shown limited efficacy and have recently come under increased FDA scrutiny. Unlike small molecule drugs, cell and genetic therapies remain challenged by high cost and significant manufacturing and regulatory hurdles.

Revidia Therapeutics is addressing the main cause of mortality in DMD patients: Heart failure

Revidia’s lead pipeline asset is MSI-1436, a first-in-class small molecule for activating intrinsic regenerative processes in the heart.

MSI-1436 selectively reduces the activity of protein tyrosine phosphatase 1B or PTP1B.

High levels of PTP1B activity function as a “molecular brake” 
on innate tissue repair and regeneration processes. MSI-1436 reduces PTP1B activity and releases that molecular brake.

MSI-1436 activates multiple, novel MOAs and restores the heart’s innate capacity for repair and regeneration lost postnatally.

MSI-1436 has established human safety with an estimated safety margin of up to 50-fold.

“It is surprising that a single molecule has such extensive and complete effects”

Sir Nilesh Samani, MD: Professor of Cardiology
at the University of Leicester

Williams, Oscar. “Drug Could Regenerate Damaged Tissue After A Heart Attack, Study Suggests.” HuffPost UK, 14 Mar. 2017.

Expected clinical benefits of MSI-1436 for DMD patients

Long-term reparative and regenerative structural changes to the heart

Improved function: increased LV ejection fraction and reduced RV wall degeneration

Lasting improvement in heart function after treatment is stopped

Increased quality of life and extended life expectancy

“I have not seen such striking data as this with a small molecule alone”

Angela Russell, DPhil: Professor of Medicinal
Chemistry at the University of Oxford 

“Could a New Drug Unlock Our Ability to Heal Damaged Tissue?” Undark, 16 Mar. 2017.

Our paradigm shifting approach focuses on activating intrinsic regenerative mechanisms in damaged tissues using small molecule drugs.

A different approach, a shared goal:
Improving the lives of heart disease patients

MISSION

Revidia Therapeutics was founded to address the limitations of current cardiac regenerative medicine R&D. Our paradigm shifting approach utilizes novel animal models to identify drug candidates with the ability to reactivate the innate regenerative capacity in damaged heart muscle.

TEAM

We have assembled a team of experts dedicated to challenging the status quo in the treatment of heart injury. Our scientists, clinicians, and drug developers bring a wealth of experience and a shared passion for improving the lives of heart disease patients.

VALUES

We are driven by a commitment to scientific excellence, patient-centricity, and a belief in the power of innovation to transform lives.

Leadership Team

Kevin Strange, Ph.D.

Founder and Chief Executive Officer
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Michael Christensen, Ph.D.

Executive Vice President for Business Development
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Michael Stein, M.D., F.A.C.C.

Vice President for Clinical Development
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Scientific Advisory Board

Richard T. Lee, M.D.

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Thomas A. Rando, M.D., Ph.D.

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Medical Advisory Board

Linda Cripe, M.D.

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Jennifer Monti, M.D., M.P.H.

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News

News Release 8 Jan 2025

Revidia Therapeutics expands leadership team

Also awarded a small business innovation research grant from the National Heart, Lung, and Blood Institute.

The role of PTP1B inhibitors in tissue regeneration.

Regenerative medicine holds substantial promise for repairing or replacing tissues and organs damaged by disease, injury, and degeneration. Development of small molecule regenerative medicine therapies is an emerging area.

Developing small molecule therapeutics to tackle heart failure in DMD patients

Duchenne muscular dystrophy (DMD) is an X-linked orphan disease caused by mutations in the dystrophin gene, the largest and most complex gene in the human genome.

Get in touch

If you are interested in learning more about Revidia’s programs and investment and partnership opportunities, please fill out our form or contact us